One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions |
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Authors: | Zahed Karimi-Jaberi Mohammad Barekat |
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Institution: | Department of Chemistry, Islamic Azad University, Firoozabad Branch, P. O. Box 74715-117, Firoozabad, Fars, Iran |
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Abstract: | Sodium dihydrogen phosphate (NaH2PO4) efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra- substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH2PO4. |
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Keywords: | Sodium dihydrogen phosphate Imidazoles Benzil Solvent-free |
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