| 手性氨基酚催化二乙基锌对芳香醛的不对称加成反应 |
| |
| 引用本文： | 李新生,沈宗旋,葛健锋,张雅文. 手性氨基酚催化二乙基锌对芳香醛的不对称加成反应[J]. 有机化学, 2003, 23(4): 387-389 |
| |
| 作者姓名： | 李新生 沈宗旋 葛健锋 张雅文 |
| |
| 作者单位： | 苏州大学化学化工系,苏州,215006 |
| |
| 摘 要： | 用易得的原料合成了4个手性氨基酚，这些化合物成功地催化了二乙基锌对醛 的不对称加成反应．其中1a催化间氯苯甲醛和二乙基锌的加成反应获得了较高的化 学产率(95％)和较好的ee值(57％)．
|
| 关 键 词： | 氨基酚 锌化合物 芳香族醛 不对称合成 加成反应 催化反应 |
| 修稿时间： | 2002-07-15 |
Enantioselective Addition of Diethylzinc to Aromatic Aldehydes with Aminohenol as Catalysts |
| |
| LI,Xin Sheng SHEN,Zong Xuan GE,Jian Feng ZHANG,Ya Wen. Enantioselective Addition of Diethylzinc to Aromatic Aldehydes with Aminohenol as Catalysts[J]. Chinese Journal of Organic Chemistry, 2003, 23(4): 387-389 |
| |
| Authors: | LI Xin Sheng SHEN Zong Xuan GE Jian Feng ZHANG Ya Wen |
| |
| Affiliation: | Department of Chemistry and Chemical Engineeing,Suzhou University |
| |
| Abstract: | Four aminophenols have been prepared and evaluated as the catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes. Ligand 1a was found to show the best asymmetric induction in the catalysis of the reaction of m chlorobenzaldehyde to provide sec alcohol with high yield (95%) and moderate ee (57%). |
| |
| Keywords: | chiral aminophenol addition diethylzinc |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
|
点击此处可从《有机化学》下载全文 |
