Asymmetric 1,4-addition of β-keto esters to cyclic enones catalyzed by Ru amido complexes |
| |
Authors: | Hui Wang |
| |
Affiliation: | Graduate School of Science and Engineering, Tokyo Institute of Technology and Frontier Collaborative Research Center, O-okayama, Meguro-ku, Tokyo 152-8552, Japan |
| |
Abstract: | Well-defined Ru amido complexes effected asymmetric Michael addition of β-keto esters to 2-cyclopenten-1-one to give quantitatively the corresponding Michael adducts with excellent ee although with a 1:1 diastereomer ratio. The stereochemical outcome of the reaction was significantly influenced by the structures of the catalysts and the structures of the β-keto esters; the ee value reaching up to 97%. |
| |
Keywords: | Multifunctional catalyst Ru amido complex Michael reaction Asymmetric C-C bond formation |
本文献已被 ScienceDirect 等数据库收录! |