Heteroatom transfer to alkenes by N-protected-oxaziridines: new reaction pathways and products |
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| Authors: | Alan Armstrong Ian D Edmonds |
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| Institution: | a Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK
b Neurology and Gastrointestinal Diseases Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK |
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| Abstract: | N-Alkoxycarbonyl- and N-carboxamido-oxaziridines are shown to react with aromatic alkenes to give epoxide, aziridine or hydro-oxidation products, in ratios depending on the oxaziridine structure. Chiral oxaziridines can effect epoxidation and hydro-oxidation with promising levels of asymmetric induction. |
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| Keywords: | Oxaziridines Amination Aziridines Epoxides |
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