Synthesis of new axially dissymmetric ligand with large perfluoroalkyl groups |
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Authors: | Masaaki Omote |
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Affiliation: | Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata 573-0101, Japan |
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Abstract: | A new axially dissymmetric ligand with large perfluoroalkyl groups, 2,2′-bis(1-hydroxy-1H-perfluorooctyl)biphenyl (1c), which could not be obtained by the coupling reaction of the aryl bromide using copper powder, was synthesized successfully by the coupling reaction using Ni(COD)2. This ligand showed much higher asymmetric induction in the reaction of diethylzinc with benzaldehyde than the trifluoromethyl (1a) or pentafluoroethyl (1b) analogues. |
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Keywords: | Fluorine Chiral Axial dissymmetry Ligand Coupling reaction Asymmetric synthesis |
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