Studies on 6-[(dimethylamino)methylene]aminouracil: a facile one-pot synthesis of novel pyrimido[4,5-d]pyrimidine derivatives |
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| Authors: | Dipak Prajapati Ashim J. Thakur |
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| Affiliation: | a Department of Medicinal Chemistry, Regional Research Laboratory, Jorhat 785 006, Assam, India
b Department of Chemical Sciences, Central University, Tezpur 784028, India |
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| Abstract: | The reactions of 6-[(dimethylamino)methylene]aminouracil 1, with various heterocumulenes such as aryl isocyanates and isothiocyanates give rise to novel pyrimido[4,5-d]pyrimidines in excellent yields, after elimination of dimethylamine from the (1:1) cycloadducts and tautomerisation. This procedure provides a convenient method for direct synthesis of pyrimido[4,5-d]pyrimidine derivatives under thermal conditions. |
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| Keywords: | Amidines Pyrimido[4,5-d]pyrimidines Aryl isothiocyanates Aryl isocyanates |
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