Facile, chemoenzymatic synthesis of the potent antiviral compound, 2-acetonylinosine |
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| Authors: | Mukta Gupta |
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| Institution: | Department of Pharmaceutical and Biomedical Sciences and The Center for Drug Discovery, University of Georgia, Athens, GA 30602, USA |
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| Abstract: | A facile and efficient methodology for the chemoenzymatic synthesis of the antiviral compound, 2-acetonylinosine has been developed. The present synthetic strategy, which has generality, is a dramatic improvement on the methodologies currently available for the synthesis of functionalized purine nucleosides of therapeutic interest. |
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| Keywords: | Regiospecific functionalization Enzyme-mediated synthesis Antiviral nucleoside |
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