An exception to the normal Mitsunobu reaction with phenols; the formation of hydrazones from salicylaldehydes |
| |
| Authors: | Mario Girard Philippe Murphy |
| |
| Institution: | a Department of Medicinal Chemistry, Merck Frosst Canada & Co., PO Box 1005, Pointe Claire-Dorval, Que., Canada H9R 4P8
b Merck Research Laboratories, PO Box 2000, MS: R50-105, Rahway, NJ 07065, USA |
| |
| Abstract: | The reaction of 2-hydroxybenzaldehydes with alkanols in the presence of triphenylphosphine and di-tert-butyl azodicarboxylate (DBAD), under the Mitsunobu reaction conditions, gives rise to the formation of hydrazones as the major products rather than the expected alkyl aryl ethers. |
| |
| Keywords: | Mitsunobu Hydrazone Salicylaldehyde |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
