Carbolithiation of vinyl pyridines as a route to 7-azaindoles |
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| Authors: | Bertrand Cottineau |
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| Institution: | Centre for Synthesis and Chemical Biology, Conway Institute, Department of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | An effective synthesis of the 7-azaindole ring system has been developed from substituted 2-amino-3-vinyl pyridines. The methodology involves a novel cascade reaction sequence of controlled carbolithiation of the vinyl double bond, subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by ring closure and dehydration. |
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| Keywords: | 7-Azaindole Carbolithiation Cascade reaction |
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