Photooxygenation of 3-aryl-2-cyclohexenols: synthesis of a new series of antimalarial 1,2,4-trioxanes |
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| Authors: | Chandan Singh Nitin Gupta |
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| Affiliation: | a Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India
b Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India |
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| Abstract: | Using easily accessible 3-aryl-2-cyclohexenols, a photooxygenation route for the preparation of bicyclic 1,2,4-trioxanes is reported. Several of these trioxanes have shown significant antimalarial activity against multidrug resistant Plasmodium yoelii in mice by the oral route. |
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| Keywords: | Antimalarial 1,2,4-Trioxane Photooxygenation Plasmodium yoelii |
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