A practical synthesis of highly functionalized aryl nitriles through cyanation of aryl bromides employing heterogeneous Pd/C |
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| Authors: | Masanori Hatsuda |
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| Affiliation: | a Process Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan
b Export and Import Group, Purchasing Department, Logistics Division, Tanabe Seiyaku Co., Ltd, 3-2-10, Dosho-Machi, Chuo-Ku, Osaka 541-8505, Japan |
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| Abstract: | An industrially viable cyanation of aryl bromides with Zn(CN)2 was accomplished in the presence of inexpensive and readily accessible Pd/C, Zn dust, ZnBr2, and PPh3 in DMA to provide functionalized aryl nitriles in moderate to high yields. |
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