Efficient cleavage of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H2SO4 in CH2Cl2 |
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| Authors: | Paolo Strazzolini Nazareno Misuri Pierluigi Polese |
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| Affiliation: | Department of Chemical Sciences and Technologies, University of Udine, via del Cotonificio 108, I-33100 Udine, Italy |
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| Abstract: | A new procedure for the deprotection of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H2SO4 in CH2Cl2 is described. The proposed method is simple, cheap, eco-friendly and represents a valid alternative to existing ones, with special significance in large scale applications. |
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| Keywords: | Sulfuric acid Dichloromethane Deprotection tert-Butyl ester N-Boc-amine |
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