New enantioselective method for hydration of alkenes using cyclodextrins as phase transfer catalyst |
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| Authors: | Artur R. Abreu,Carla Rosa,Ana Lourenç o |
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| Affiliation: | a REQUIMTE, Departamento de Química, FCT-UNL, 2829-516 Caparica, Portugal
b CQE, Instituto Superior Técnico, Departamento de Enga Química, UTL, Avenida Rovisco Pais, 1049-001 Lisboa, Portugal |
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| Abstract: | A new enantioselective/inverse phase transfer catalysis (IPTC) reaction for the Markovnikov hydration of double bounds by an oxymercuration-demercuration reaction with cyclodextrins as catalysts was disclosed. Moderate ee (up to 32%) and yields (14-60%) were obtained for allylic amines and protected allylic alcohols as starting materials. |
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| Keywords: | Reduction IPTC Oxymercuration Cyclodextrin Hydration |
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