Enantioselective Morita-Baylis-Hillman (MBH) reaction promoted by a heterobimetallic complex with a Lewis base |
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| Authors: | Katsuya Matsui |
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| Institution: | The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan |
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| Abstract: | A new double-activation catalysis is presented for the Morita-Baylis-Hillman (MBH) reaction of an α,β-unsaturated ketone and an aldehyde by the combined use of a heterobimetallic asymmetric complex and tributylphosphine ((n-Bu)3P) to afford the α-methylene-β-hydroxy ketone with up to 99% ee. |
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| Keywords: | Double-activation Morita-Baylis-Hillman (MBH) reaction |
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