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Bioluminescence activity of Latia luciferin analogues: replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups |
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| Authors: | Mitsuhiro Nakamura Masashi Mamino Shojiro Maki Satoshi Kojima Yoshihiro Ohmiya |
| Institution: | a Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan b Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan c Highthroughput Factory, RIKEN Harima Institute, Sayo-gun, Hyogo 679-5148, Japan |
| Abstract: | A series of Latia luciferin analogues having methyl-substituted phenyl groups instead of the natural 2,6,6-trimethylhexene ring was synthesized and their bioluminescence activity were measured. The Latia luciferase was found to be able to moderately recognize the appropriately methyl-substituted phenyl analogues with the same light production kinetics as that of natural luciferin. |
| Keywords: | Latia neritoides Luciferin Luciferase Bioluminescence |
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