TiCl(OPr)3 and NaBH(OAc)3: an efficient reagent combination for the reductive amination of aldehydes by electron-deficient amines |
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| Authors: | Corey D Gutierrez |
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| Institution: | Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, Chemistry Department, Cancer Research UK Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK |
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| Abstract: | Sodium triacetoxyborohydride, NaBH(OAc)3 with tri-isopropoxytitanium chloride, TiCl(OiPr)3 is a useful reagent combination for reductive amination. Electron-deficient amines and heteroaromatic amines such as 2-aminopyrimidine and 2-aminothiazole can be reductively alkylated at room temperature to afford the corresponding secondary amines in good yields. |
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