The first example of magnesium carbenoid 1,3-CH insertion reaction: a novel method for synthesis of cyclopropanes from 1-chloroalkyl phenyl sulfoxides in high yields |
| |
| Authors: | Tsuyoshi Satoh Jun Musashi Atsushi Kondo |
| |
| Affiliation: | Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan |
| |
| Abstract: | Treatment of 1-chloroalkyl phenyl sulfoxides having a geminal methyl group or a geminal benzyl group at the 2-position in THF at −78 °C with isopropylmagnesium chloride gave magnesium carbenoids. Carbenoid 1,3-CH insertion reaction of the magnesium carbenoids took place instantaneously to afford cyclopropanes in high to quantitative yields. |
| |
| Keywords: | Cyclopropane Sulfoxide Sulfoxide-magnesium exchange Magnesium carbenoid C-H insertion |
| 本文献已被 ScienceDirect 等数据库收录！ |
