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Total synthesis of psorospermin |
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| Authors: | Michael K. Schwaebe Terence J. Moran Jeffrey P. Whitten |
| Affiliation: | Department of Medicinal Chemistry, Cylene Pharmaceuticals Inc., 11045 Roselle St. Suite C, San Diego, CA 92121, USA |
| Abstract: | The xanthone natural product psorospermin was synthesized in 13 steps with an overall yield of 1.7%. This compound shows potent antineoplastic activity in a variety of cancer cell lines. |
| Keywords: | Psorospermin Asymmetric synthesis Anticancer agent Xanthone Natural product |
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