A simple and convenient procedure for the synthesis of 1-aminophosphonates from aromatic aldehydes |
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Authors: | Babak Kaboudin Khavar Moradi |
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Institution: | Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran |
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Abstract: | A simple, efficient, possible industrial process has been developed for the synthesis of 1-aminophosphonic acids from simple starting materials. As described below, treatment of aromatic aldehydes with ammonia and reaction with diethyl phosphite gives diethyl N-(arylmethylene)-1-aminoaryl methylphosphonates, which can be easily hydrolyzed to diethyl 1-aminoarylmethylphosphonates. This method is easy, rapid, and good yielding for the synthesis of 1-aminoalkylphosphonates from simple starting materials. |
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Keywords: | 1-Aminophosphonates Aldehydes Ammonia Diethylphosphite |
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