A route to the fully substituted cyclopentane unit of viridenomycin using a tandem radical cyclisation-trapping strategy |
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| Authors: | Nicholas P Mulholland |
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| Institution: | School of Chemistry, The University of Nottingham, Nottingham NG7 2RD, England, UK |
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| Abstract: | A silicon-tethered intramolecular radical cyclisation, in tandem with a radical trapping with allyltri-n-butylstannane forms the basis of a new synthetic strategy to the cyclopentane core of the antitumoral antibiotic substance viridenomycin isolated from Streptomyces viridochromogenes and S. gannmycicus. |
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