A Stille biaryl-coupling approach to dityrosines. Formal total synthesis of Hazimycin |
| |
| Authors: | Said Achab Laurence Velay |
| |
| Institution: | Institut de Chimie des Substances Naturelles, CNRS, 91 198 Gif-sur-Yvette, France |
| |
| Abstract: | The Stille cross-coupling reaction between 3-tributylstannyltyrosine derivatives (15-23, 40), and 3-iodotyrosines (6-14, 39) afforded the corresponding dityrosines (24-37, 41). Additionally, this method provided a short and improved access to Hazimycin (3) a naturally occurring anti-fungal agent. |
| |
| Keywords: | Dityrosines Stille cross-coupling Hazimycin Stannyl tyrosines |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
