Synthesis of hemicyanine dyes for ‘click’ bioconjugation |
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| Authors: | Wen-hai Zhan Hannah N. Barnhill Krishnamoorthy Sivakumar Qian Wang |
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| Affiliation: | a Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China
b Departments of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA |
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| Abstract: | A new type of 2-propynyl substituted hemicyanine dyes have been synthesized in a facile route, which have showed superior solubility in water and good optical properties. The terminal alkynyl groups were employed for bioconjugation through a 1,3-dipolar cycloaddition with azides under mild conditions. |
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| Keywords: | Click reaction Hemicyanine dye 1,3-Dipolar cycloaddition Bioconjugation Cowpea mosaic virus |
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