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Practical and efficient synthesis of N-halo compounds |
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| Authors: | Yong-Li Zhong Hua Zhou Donald R Gauthier Jaemoon Lee David Askin Ulf H Dolling Ralph P Volante |
| Institution: | Department of Process Research, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | A practical and efficient synthesis of N-halo compounds is described. Treatment of primary and secondary amines or amides with sodium hypohalite in the presence of tert-butanol and acetic acid afforded N-halo compounds in 90-100% yield. |
| Keywords: | Amine oxidation Amide oxidation N-halogenation Sodium hypohalite tert-Butyl hypohalite |
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