Pyrene-labeled deoxyuridine and deoxyadenosine: fluorescent discriminating phenomena in their oligonucleotides |
| |
| Authors: | Gil Tae Hwang |
| |
| Affiliation: | National Research Laboratory, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea |
| |
| Abstract: | Pyrene-labeled deoxyuridine (UP) and deoxyadenosine (AP) units, which are substituted at the C-5 and C-8 positions, respectively, are fluorescent unnatural nucleosides. When duplexes are formed, these nucleobases feature strong and stable interstrand stacking interactions between the two pyrene units, which compensate for the loss of hydrogen bonding and induce characteristic pyrene excimer emissions. |
| |
| Keywords: | Fluorescence Excimer Interstrand stacking Nucleotides |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
