Pictet-Spengler heterocyclizations via microwave-assisted degradation of DMSO |
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| Authors: | Christophe Mé sangeau,Basile Pé rè s,Thierry Besson |
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| Affiliation: | a Laboratoire de Chimie Thérapeutique, EA1043, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
b Laboratoire de Biotechnologies et Chimie Bio-organique, FRE CNRS 2766, UFR Sciences Fondamentales et Sciences pour l’Ingénieur, Bâtiment Marie Curie, Université de La Rochelle, F-17042 La Rochelle Cedex 1, France |
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| Abstract: | For the first time the ability of DMSO to decompose rapidly under microwaves was explored in order to perform heterocyclizations in good conditions. This modified Pictet-Spengler reaction allowed, in this case, the synthesis of rigidified melatonin analogues. |
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| Keywords: | Microwave-assisted reactions Dimethyl sulfoxide Formaldehyde Pictet-Spengler heterocyclization |
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