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An efficient preparation of stereospecific β-hydroxy nitriles |
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| Authors: | Sheila H Jacobo Chih-Tsung Chang William S Powell |
| Institution: | a Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 W. University Blvd., Melbourne, FL 32901, USA b Eczacibasi Fine Chemical Products, Organize Sanayani Bolgesi, Fatih Cad. No 12, Cerkezkoy 59500, Tekirdag, Turkey c Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626 St-Urbain Street, Montreal, Canada QC H2X 2P2 |
| Abstract: | The cyanide-ring opening of thionocarbonates with NaCN in DMF and TBACN in THF is described. This reaction occurred regioselectively to afford β-hydroxy nitrile with preserved stereochemistry of the hydroxy group in high yield. |
| Keywords: | Thionocarbonates β-Hydroxy nitrile Cyanide diHETEs 5-HETE 5-Oxo-ETE |
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