Three-component synthesis of polysubstituted benzene derivatives via Diels-Alder reaction of cyclopentadienone acetal with alkyne |
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Authors: | Sota Sato Takatsugu Tanaka |
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Affiliation: | Department of Chemistry and ERATO (JST), The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
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Abstract: | An efficient and regioselective synthesis of polysubstituted benzene derivatives was achieved via multicomponent reaction of a substituted cyclopropenone acetal and two alkyne molecules. The synthesis utilizes cyclopentadienone acetal as an intermediate and enables regioselective [2+2+2] assembly of the three-components into a benzene ring. A variety of polysubstituted benzene derivatives of synthetic and structural interest have been synthesized. |
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Keywords: | Polysubstituted benzene Three-component [2+2+2] synthesis Diels-Alder reaction Cyclopropene Cyclopentadiene |
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