Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones |
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| Authors: | Ji-Feng Liu Jaekyoo Lee Grace Bi Carmen M. Baldino Matt Brown |
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| Affiliation: | a Division of Chemical Technologies, ArQule, Inc., 19 Presidential Way, Woburn MA 01801, USA
b Pfizer Global Research and Development, Pfizer Inc., Eastern Point Road, Groton CT 06340, USA |
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| Abstract: | A practical synthesis of 2,3-disubstituted 3H-quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles. |
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| Keywords: | Microwave Quinazolinone |
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