Radical deoxygenation of alcohols and intermolecular carbon-carbon bond formation with surfactant-type radical chain carriers in water |
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| Authors: | Dae Hyan Cho |
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| Affiliation: | a Department of Chemistry, Yonsei University, Wonju 220-710, Republic of Korea
b Center for Bioactive Molecular Hybrids, Yonsei University, Seoul 120-749, Republic of Korea |
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| Abstract: | An efficient and mild method is developed for radical deoxygenation of alcohols and formation of carbon-carbon bonds in water without adding additives such as surfactants. The reaction was applied to synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides that are potent anti-HIV agents. The reaction afforded environmentally benign reaction conditions. |
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| Keywords: | Radical water Phosphorus hydride Deoxygenation Surfactant C-C bond formation |
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