Asymmetric hydrogenation of imines catalyzed by iridium complexes with phosphine-phosphite ligands: importance of backbone flexibility |
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| Authors: | Sergio Vargas |
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| Institution: | Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Científicas-Universidad de Sevilla, Avda Américo Vespucio s/n, Isla de la Cartuja, 41092 Sevilla, Spain |
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| Abstract: | Chiral phosphine-phosphites provide an alternative class of ligands for the iridium catalyzed enantioselective hydrogenation of imines. Optimization of ligand structure has afforded enantioselectivities up to 84% ee in the reduction of N-aryl imines. A significant influence of backbone nature on enantioselectivity has also been observed. |
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| Keywords: | Asymmetric hydrogenation Chiral amines Phosphine-phosphites |
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