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A short synthesis of morachalcone A |
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| Authors: | Joseph J. Romano |
| Affiliation: | a Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA b Department of Chemistry, Villanova University, Villanova, PA 19085, USA |
| Abstract: | Advanced C-prenylated intermediates for three aromatase inhibitors, including morachalcone A, can be synthesized through a Claisen-Schmidt condensation followed by Florisil®-catalyzed [1,3]-sigmatropic rearrangement of a prenyl phenyl ether. |
| Keywords: | [1,3]-Rearrangement Florisil® Chalcone |
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