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Direct access to CF3-propargyl amines and conversion to difluoromethyl imines |
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| Authors: | Guillaume Magueur Danièle Bonnet-Delpon |
| Institution: | BioCIS-CNRS, Faculté de Pharmacie-Paris Sud, rue J. B. Clément, F-92296 Châtenay-Malabry, France |
| Abstract: | Trifluoromethyl aldimines reacted with acetylides in toluene at −78 °C to provide propargyl amines in good yields. From a chiral trifluoromethyl aldimine, the propargyl amines were obtained with excellent diastereoselectivities (de >98%). Trifluoromethyl propargyl amines could be further converted into difluoromethyl imines under basic conditions. |
| Keywords: | Trifluoromethyl aldimines CF3-propargyl amines Difluoromethyl imines Difluoromethyl propargyl amines |
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