Titanocene(III) mediated radical cyclization of α-bromo carbonyl compounds: synthesis of tri-substituted tetrahydrofurans |
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| Authors: | Samaresh Jana |
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| Institution: | Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India |
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| Abstract: | A novel and efficient methodology has been developed for the construction of synthetically important tri-substituted tetrahydrofuran derivatives from bromo-alkenes and bromo-alkynes by radical cyclization reactions using the radical initiator Cp2TiCl, generated in situ from commercially available titanocene dichloride and Zn dust in tetrahydrofuran under argon. |
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| Keywords: | Titanocene(III) Radical cyclization Bromo-alkenes and alkynes |
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