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Stereoselective synthesis of (−)-microcarpalide |
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| Authors: | Subhash P. Chavan Cherukupally Praveen |
| Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India |
| Abstract: | A highly convergent and efficient synthesis of (−)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strategy highlights the application of novel hydroxy lactone precursors for the stereoselective synthesis of (−)-microcarpalide. |
| Keywords: | Microcarpalide Ring-closing metathesis Sharpless asymmetric dihydroxylation Claisen ortho ester rearrangement cis-2-Butene-1,4-diol |
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