Synthesis of butyrolactones by nickel-catalyzed reductive cyanation of alkynols in water |
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| Authors: | José Luis Garcí a Gutié rrez,Federico Jimé nez-Cruz |
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| Affiliation: | a Instituto Mexicano del Petróleo. Eje Central Lázaro Cárdenas 15, México DF 07730, México
b Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México DF 04510, México |
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| Abstract: | One-pot catalytic synthesis of butyrolactones from alkynols under mild conditions is described here. The methodology involves the use of the K2[Ni(CN)4]/NaBH4 system in presence of KCN and water. According to the experimental evidences, a possible mechanism pathway is suggested, which involves the nickel-catalyzed reductive cyanation of alkynol, followed by nitrile hydration, reduction of double bond and lactonization. |
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| Keywords: | Alkynol Lactone Nickel Cyanide Borohydride Cyanation Catalysis |
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