A study of polymer-supported bases for the solution phase synthesis of glycosyl trichloroacetimidates |
| |
| Authors: | Jose Luis Chiara |
| |
| Institution: | Instituto de Química Orgánica General, CSIC, Juan de la Cierva, 3, E-28006 Madrid, Spain |
| |
| Abstract: | Polystyrene-supported strong organic bases are highly efficient reagents for the solution-phase synthesis of glycosyl trichloroacetimidates, affording quantitative yields of pure products in short reaction times after simple filtration and evaporation. Although efficiency of the different bases varies with substrate structure, polymer-bound 1,8-diazabicyclo5.4.0]undec-7-ene was found to give the best results for all the substrates tested. |
| |
| Keywords: | Carbohydrates Solid-supported reagents Glycosylation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
