Palladium-catalyzed cross-coupling reaction of alkynylzincs with benzylic electrophiles期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Palladium-catalyzed cross-coupling reaction of alkynylzincs with benzylic electrophiles

Authors:	Mingxing Qian

Institution:	Herbert C. Brown Laboratories of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, USA

Abstract:	The reaction of alkynylzinc bromides with benzyl bromides or chlorides in the presence of a catalytic amount of Pd(DPEphos)Cl₂ in THF at 23 °C cleanly produces the corresponding benzylated alkynes in 73-97% yields. With 10⁻³ mol % of Pd(DPEphos)Cl₂, the maximum turnover number of 7.1 × 10⁴ has been observed for the formation of PhCCCH₂Ph.

Keywords:	Palladium-catalyzed cross-coupling Alkynylzincs Benzylic electrophiles Benzylated alkynes Pd(DPEphos)Cl₂
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