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Vesicle formation from a synthetic adenosine based lipid |
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| Authors: | Louis Moreau Philippe Barthélémy |
| Institution: | a Faculté des sciences d’Avignon 33, rue Louis Pasteur, F-84000, Avignon, France b Department of Chemistry and Department of Biomedical Engineering, Metcalf Center for Science and Engineering, Boston University, Boston, MA 02215, USA |
| Abstract: | We report the synthesis of a novel purine based amphiphile; di-oleyladenosinephosphocholine (DOAPC). Light microscopy, TEM and QELS studies on DOAPC in aqueous media support the formation of lamellar systems. These investigations indicate that the presence of adenine does not prohibit the formation of lamellar organizations. Stable small unilamellar vesicles can be prepared by using extrusion techniques. |
| Keywords: | Lipids Nucleolipids Supramolecular structures Vesicles Nucleoside |
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