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Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands |
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| Authors: | Yong-feng Kang Rui Wang Lei Liu Wen-jin Yan Zhao-qing Xu |
| Institution: | a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China b Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000,China |
| Abstract: | New chiral oxazolidines were conveniently synthesized from natural amino acids in three simple steps with good yields. The use of chiral oxazolidine ligands for the enantioselective alkynylation of aldehydes provides a simple, practical and inexpensive method to generate chiral propargyl alcohols with 85-99% ee. |
| Keywords: | Aldehydes Alkynes Oxazolidines Addition Asymmetric catalysis |
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