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A novel and unusual method for C-N bond formation in 1-substituted-pyrrolidin-2-ones |
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| Authors: | Neelima Sinha Nitya Anand |
| Institution: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226 001, India |
| Abstract: | A novel 5-C-N bond forming reaction is reported, which involves heating 1-substituted-pyrrolidin-2-ones with cyclic amines in the presence of a base. This reaction provides a convenient method for the synthesis of 1,5-disubstituted-pyrrolidin-2-ones. |
| Keywords: | 1-Substituted-pyrrolidin-2-ones 5-C-N bond formation 1 5-Disubstituted-pyrrolidin-2-ones Formylation 1 3-Disubstituted-pyrrolidin-2-ones |
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