A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent |
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| Authors: | Kai Rossen Pavol Jakubec Matthias Janik |
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| Affiliation: | a Degussa AG, EC-EX-R&D-WO, Rodenbacher Chaussee 4, 63457 Hanau, Germany
b Degussa AG, Aqura NMR Department, Rodenbacher Chaussee 4, 63457 Hanau, Germany |
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| Abstract: | Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl β-amino acid esters in good yield, which can be kinetically resolved with a lipase. |
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| Keywords: | β-Amino acid Ketene diethylacetal Acyl imine Acetate enolate Enzymic kinetic resolution |
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