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Thermal and microwave-assisted N-formylation using solid-supported reagents
Authors:Bimbisar Desai  Timothy N Danks  Gabriele Wagner
Institution:a Chemistry Division, SBMS, University of Surrey, Guildford, Surrey GU2 7XH, UK
b The Oratory School, Woodcote, Reading RG8 0PJ, UK
Abstract:A rapid and easy route to formamides by microwave assisted N-formylation of primary and secondary amines is described. Using an insoluble polymer or an inorganic solid-supported reagent as a formylating agent, microwave irradiation furnished the corresponding formamides in high yields, with reduced reaction time and solvent volume over the conventional approach.
Keywords:Formamides  Microwave irradiation  Solid-supported formate
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