Synthesis of benz[5,6]azepino[4,3-b]indoles by 1,7-electrocyclisation of azomethine ylides |
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| Authors: | Mikló s Nyerges,Á ron Pinté r,Istvá n Bitter |
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| Affiliation: | a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest, PO Box 91, Hungary
b Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest, PO Box 91, Hungary |
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| Abstract: | A new, general route to the benz[5,6]azepino[4,3-b]indole ring system has been developed via the 1,7-dipolar electrocyclisation reactions of azomethine ylides derived from easily available 3-formyl indole derivatives. The intermediacy of azomethine ylides was shown by the trapping of the proposed α,β:γ,δ-conjugated dipole with N-phenylmaleimide. |
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| Keywords: | Azomethine ylide Cycloaddition Electrocyclisation Indole |
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