Solid-phase synthetic method for (±)-α-amino acids via phase-transfer catalytic alkylation |
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| Authors: | Hyeung-geun Park Mi-Jeong Kim |
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| Affiliation: | Research Institute of Pharmaceutical Science and College of Pharmacy, Seoul National University, Seoul 151-742, Korea |
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| Abstract: | A solid supported glycineimine t-butyl ester was designed and successfully applied to the synthesis of (±)-α-amino acids. The phase-transfer catalytic alkylation, followed by acidic hydrolysis and benzoylation gave N-benzoyl-α-amino acid tert-butyl esters in high yields (up to 92%). |
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| Keywords: | Phase-transfer catalytic alkylation Solid-phase synthesis α-Amino acid |
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