Microwave-assisted, regioselective, Petasis olefination of unsymmetrical oxalates. Formation of pyruvate-based enol ethers and enamines |
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| Authors: | Matthew J Cook |
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| Institution: | School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom |
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| Abstract: | The Petasis olefination of unsymmetrical oxalates and oxalate monoesters/monoamides (tert-BuO2CC(O)X, where X = OR, NR2) is highly regioselective and provides pyruvate-based enol ether and enamine derivatives. The olefination step occurs under conventional thermal conditions, but is dramatically improved--shorter reaction times and higher yields--when promoted by microwave irradiation. |
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| Keywords: | Petasis reagent Olefination Pyruvates Enamines Enol ethers |
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