An efficient catalytic asymmetric addition of trimethylsilyl cyanide to aldehydes at room temperature |
| |
| Authors: | Zi-Bo Li |
| |
| Affiliation: | Department of Chemistry, University of Virginia, Charlottesville, Virginia, VA 22904-4319, USA |
| |
| Abstract: | The BINOL-salen compound (S)-5c in combination with Ti(OiPr)4 is found to catalyze the addition of TMSCN to aldehydes to form chiral cyanohydrins with very good enantioselectivity (75-85% ee). The reactions are carried out in one-pot at room temperature without the need to isolate the chiral Lewis acid catalyst. |
| |
| Keywords: | Cyanohydrin Enantioselective Trimethylsilyl cyanide addition Aldehydes Salen BINOL |
| 本文献已被 ScienceDirect 等数据库收录！ |
