Cyclisation at very high temperature. Thermal transformations of N-alkyl and N,N-dialkyl cinnamic amides into pyrrolidin-2-ones under FVT conditions |
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Authors: | Stanis?aw Le?niak Beata Pasternak |
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Affiliation: | Department of Organic and Applied Chemistry, University of ?ód?, Narutowicza 68, 90-136 ?ód?, Poland |
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Abstract: | Novel cyclisations of N-alkyl and N,N-dialkyl cinnamic amides to the corresponding pyrrolidin-2-ones under the conditions of flash vacuum thermolysis, are described. It was found that this reaction proceeds at 950-1000 °C affording a mixture of isomeric pyrrolidin-2-ones in various yields. Two possible mechanisms are proposed for the process. |
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Keywords: | Amides Cyclisation Flash vacuum thermolysis γ-lactams |
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