A mild and efficient one-step synthesis of quinolines |
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| Authors: | Surya K De Richard A Gibbs |
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| Institution: | Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47906, USA |
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| Abstract: | 2-Aminoaryl ketones undergo condensation with α-methylene ketones in the presence of a catalytic amount of Y(OTf)3 at room temperature under mild conditions to afford the corresponding polysubstituted quinolines in excellent yields. |
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