Coordination mode for turn-based phosphine ligands: the origin of selectivity in Pd catalysis |
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| Authors: | Anton Agarkov |
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| Affiliation: | a Department of Chemistry, Washington University, St. Louis, MO 63130, USA
b Chemical Biology Program, Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555-0650, USA |
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| Abstract: | A series of experiments was performed to determine the nature of the catalyst in peptide-derived phosphine ligands. The selectivity of the catalyst system was determined with four ligands that are diastereomeric at the phosphine containing amino acid. Additionally, a series of monophosphine ligands was synthesized and screened to determine if the active catalysts are derived from a phosphine-amide complex. |
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| Keywords: | Phosphine Palladium Allylation β-turn |
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