Convenient synthesis of 7-hydroxyindole |
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| Authors: | Kazunao Ishiyama |
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| Affiliation: | Department of Applied Biological Science, Faculty of Life Science, Fukuyama University, 729-0292 Fukuyamashi, Hiroshima, Japan |
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| Abstract: | 7-Hydroxyindole, the key building block for the synthesis of AJ-9677 1, was prepared from indoline in six steps in 36% overall yield. AJ-9677 1 is a potent and selective adrenaline β3-agonist being considered as a clinical candidate to treat obesity in those who are suffering from diabetes. |
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